Metagenomic analysis of human fecal samples

Lund University intends to order Metagenomic analysis of human fecal samples from large population based studies [Malmö Offspring Study (MOS) and SCAPIS-Malmö] for a research project within the Department of Medical Sciences at Lund University.

Scope

The primary scope:

Analysis of around 3000 MOS and 3500 SCAPIS Malmö samples (N = approximately 6500) through 2019.

Option for the buyer to extend the contract for additional analysis throughout 2020-2023

MOS is an ongoing study and by the end of 2020 we expect another 1500-3000 samples to be analyzed. In addition, a return visit for some participants is planned in 2020-2023, it may be necessary to analyze samples from these visits.

Also, there are ongoing intervention studies and other population studies on a smaller scale compared to MOS and SCAPIS-Malmö at the institution and there are plans to carry out metagnomic sequencing on these after 2019.

Lund University intends to order Metagenomic analysis of human fecal samples from large population based studies [Malmö Offspring Study (MOS) and SCAPIS-Malmö] for a research project within the Department of Medical Sciences at Lund University.

Scope

The primary scope:

Analysis of around 3000 MOS and 3500 SCAPIS Malmö samples (N = approximately 6500) through 2019.

Option for the buyer to extend the contract for additional analysis throughout 2020-2023

MOS is an ongoing study and by the end of 2020 we expect another 1500-3000 samples to be analyzed. In addition, a return visit for some participants is planned in 2020-2023, it may be necessary to analyze samples from these visits.

Also, there are ongoing intervention studies and other population studies on a smaller scale compared to MOS and SCAPIS-Malmö at the institution and there are plans to carry out metagnomic sequencing on these after 2019.

The assignment includes:

Sample receipt and registration

DNA extraction from initially 6500 fecal samples and an option to buy additional sample analysis

DNA library preparation for shotgun metagenomics sequencing

DNA sequencing

Bioinformatic analysis and delivery of results to the customer

Shipment of original samples and DNA back to the customer (transport covered by customer)

The research project is part of the BIOMENDELIAN study with an overall aim to clarify the interplay between gut microbiota composition, diversity and functionality and dietary intakes, host genetic factors, circulating metabolites, inflammatory and satiety related proteins, and how such connections relate to risk of cardiometabolic diseases including prospective follow-up analyses.

Estimated contract start date is 2019-03-01. The contract applies from the start date up to and including 2020-08-31, the buyer is subsequently entitled to extend the contract until 2023-02-28, or depending on startdate with a maximum contractperiod of four years. Extensions may be done in several rounds for shorter or longer periods.

Contract will be signed with one (1) supplier.